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A Dialogue With the Ancient and Reflection on the Interpretation of History of Bian Que and Traditional

Fu Youfeng

Strategic Study of CAE 2005, Volume 7, Issue 12,   Pages 7-16

Abstract:

Based on the description of epidemic diseases in the chapter of “The Story of Bian Que&rdquo

Keywords： Bian Que     history of traditional Chinese medicine     the plague     febrile disease     acupuncture and moxibustion    

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Flexible micro flow sensor for micro aerial vehicles

Rong ZHU, Ruiyi QUE, Peng LIU

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4,   Pages 539-545 doi: 10.1007/s11465-017-0427-0

Abstract:

This article summarizes our studies on micro flow sensors fabricated on a flexible polyimide circuit board by a low-cost hybrid process of thin-film deposition and circuit printing. The micro flow sensor has merits of flexibility, structural simplicity, easy integrability with circuits, and good sensing performance. The sensor, which adheres to an object surface, can detect the surface flow around the object. In our study, we install the fabricated micro flow sensors on micro aerial vehicles (MAVs) to detect the surface flow variation around the aircraft wing and deduce the aerodynamic parameters of the MAVs in flight. Wind tunnel experiments using the sensors integrated with the MAVs are also conducted.

Keywords： micro flow sensor     flexible sensor     surface flow sensing     aerodynamic parameter     micro aerial vehicle (MAV)    

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Five-axis rough machining for impellers

Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 1,   Pages 71-76 doi: 10.1007/s11465-009-0010-4

Abstract: The most important components used in aerospace, ships, and automobiles are designed with free form surfaces. An impeller is one of the most important components that is difficult to machine because of its twisted blades. Rough machining is recognized as the most crucial procedure influencing machining efficiency and is critical for the finishing process. An integrated rough machining course with detailed algorithms is presented in this paper. An algorithm for determining the minimum distance between two surfaces is applied to estimate the tool size. The space between two blades that will be cleared from the roughcast is divided to generate CC points. The tool axis vector is confirmed based on flank milling using a simple method that could eliminate global interference between the tool and the blades. The result proves that the machining methodology presented in this paper is useful and successful.

Keywords： five-axis     impeller     tool-path     planning     flank milling     ruled surface    

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Retraction Note to: Simulate oil spill weathering with system dynamic model

Aihaiti Kasimu, Junran Dong, Yuan Bian, Desheng WU

Frontiers of Engineering Management   Pages 695-695 doi: 10.1007/s42524-020-0120-6

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Outdoor aging of road asphalt and SBS modified asphalt

Li XIANG, Juan TU, Jian CHENG, Guohe QUE

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 35-42 doi: 10.1007/s11705-010-0551-4

Abstract: The process of performance degradation of road asphalt (RA) is regarded as aging. At present, better understanding of the thermal-oxidative aging of asphalt is achieved and the corresponding method to evaluate this process is developed; meanwhile, photo-oxidative aging (aging in an atmospheric environment, which is referred to as “outdoor aging” in this paper) of asphalt remains at the initial stages of scientific exploration. The outdoor natural ultraviolet (UV) aging of RA and SBS modified asphalt (SBSMA) are investigated in this study. The experimental results show that the basic performances of RA and SBSMA present similar change tendencies. The softening point increased, while the penetration and ductility decreased as the outdoor aging time passed by, and the 5°C ductility (ductility measured at 5°C) of SBSMA decreased very quickly. The group components of RA and SBSMA also change during UV aging. The content of asphaltene rose and that of aromatics and saturates decreased, while the content of resins changed insignificantly. Moreover, the Fourier transform infrared (FTIR) graphs show that the content of sulfoxide and carbonyl groups in RA and SBSMA increased significantly during the outdoor aging process.

Keywords： asphalt     SBS     modified road asphalt     outdoor aging     ultraviolet    

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Current situation and development of prenatal diagnosis in China

Xu-Ming BIAN, Qi GUO, Qing-Wei QI

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 271-274 doi: 10.1007/s11684-010-0100-z

Abstract: Prenatal screening and diagnosis are major methods for control of birth defects, which is a very important problem in China. Here, we review current situation and development of prenatal screening and diagnosis in mainland China, including prenatal screening and prenatal diagnosis of fetal chromosome abnormalities, non-invasive prenatal diagnostic techniques and prenatal diagnosis of monogenic diseases, polygenic disease and congenital metabolic diseases. We also discuss epidemiology of birth defects and genetic diseases in China and related ethical issues of prenatal diagnosis.

Keywords： prenatal diagnosis     prenatal screening     China    

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Adoptive cell transfer therapy for hepatocellular carcinoma

Renyu Zhang, Zhao Zhang, Zekun Liu, Ding Wei, Xiaodong Wu, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 3-11 doi: 10.1007/s11684-019-0684-x

Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma. Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research.

Keywords： adoptive cell transfer therapy     hepatocellular carcinoma     T cell     chimeric antigen receptor     immunotherapy    

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Tests on impact effect of partial fracture at steel frame connections

CHEN Yiyi, BIAN Ruoning

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 4,   Pages 295-301 doi: 10.1007/s11709-008-0049-z

Abstract: Impact effect of sudden fracture at steel frame connections under severe earthquake or other extreme loads is presented in this paper. The relation of impulse caused by structural fracture to the release of inner force at the cracked location, the magnitude of the response to impact on the basis of one degree of freedom model, and the ratio of the peak value of response to natural period of the system are investigated. Two types of fracture tests were designed and carried out both on uniaxial steel bar tensioned and moment resistant steel frame model. It is proven that the response during the fracture process can be measured quite well using high-frequency data processing system. It is also revealed that the instant fracture of structural connection is characterized by progressive and partial fracture. Numerical evaluation of the impact effect of connection fracture is carried out.

Keywords： structural fracture     natural     fracture     progressive     high-frequency    

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Thermal performance of a single-layer packed metal pebble-bed exposed to high energy fluxes

Shengchun ZHANG, Zhifeng WANG, Hui BIAN, Pingrui HUANG

Frontiers in Energy 2021, Volume 15, Issue 2,   Pages 513-528 doi: 10.1007/s11708-019-0638-7

Abstract: It is difficult to accurately measure the temperature of the falling particle receiver since thermocouples may directly be exposed to the solar flux. This study analyzes the thermal performance of a packed bed receiver using large metal spheres to minimize the measurement error of particle temperature with the sphere temperature reaching more than 700°C in experiments in a solar furnace and a solar simulator. The numerical models of a single sphere and multiple spheres are verified by the experiments. The multiple spheres model includes calculations of the external incidence, view factors, and heat transfer. The effects of parameters on the temperature variations of the spheres, the transient thermal efficiency, and the temperature uniformity are investigated, such as the ambient temperature, particle thermal conductivity, energy flux, sphere diameter, and sphere emissivity. When the convection is not considered, the results show that the sphere emissivity has a significant influence on the transient thermal efficiency and that the temperature uniformity is strongly affected by the energy flux, sphere diameter, and sphere emissivity. As the emissivity increases from 0.5 to 0.9, the transient thermal efficiency and the average temperature variance increase from 53.5% to 75.7% and from 14.3% to 27.1% at 3.9 min, respectively. The average temperature variance decreases from 29.7% to 9.3% at 2.2 min with the sphere diameter increasing from 28.57 mm to 50 mm. As the dimensionless energy flux increases from 0.8 to 1.2, the average temperature variance increases from 13.4% to 26.6% at 3.4 min.

Keywords： packed bed     solar thermal power plants     high heat fluxes     radiative heat transfer    

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Simulate oil spill weathering with system dynamic model

Aihaiti KASIMU, Junran DONG, Yuan BIAN, Desheng WU

Frontiers of Engineering Management   Pages 696-696 doi: 10.1007/s42524-019-0060-1

Abstract: Numerous oil spill fate and trajectory models have been recently developed to predict oil spill weathering processes. However, these models separately predicted the fate of spilled oil and the change in oil properties. A system dynamic model is thus developed based on the most significant oil weathering processes, which include spreading, evaporation, dispersion into the water bulk, emulsification, and changes in viscosity and density. We employ differential equations to describe these main oil weathering processes, which vary and have different effects on each other. Oil density and viscosity are functions of evaporation and emulsification and change over time. Oil evaporation is the most important process and removes most of the spilled oil from sea surface. Considering the main oil weathering processes, our model provides a different method of predicting the fate of oil and changes in oil properties. The Alaska North Slope is selected as a case study, and the estimated fractions of evaporation are 19% and 16% at 273 K and 283 K, respectively, within 240 h. Simulation results of oil properties and fates are also presented in this study.

Keywords： oil spill     weathering     modeling     system dynamics    

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Simultaneously recovering electricity and water from wastewater by osmotic microbial fuel cells: Performance and membrane fouling

Yuqin Lu, Xiao Bian, Hailong Wang, Xinhua Wang, Yueping Ren, Xiufen Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 4, doi: 10.1007/s11783-018-1049-4

Abstract:

OsMFC can simultaneously recover electricity and water from wastewater.

Membrane fouling played an important role in flux decline of FO membrane in OsMFCs.

Biofouling was the major fouling of the FO membrane in OsMFCs.

The growth of biofouling layer on the FO membrane can be divided into three stages.

Microorganisms were the dominant biofoulant in the biofouling layer.

Keywords： Microbial fuel cell     Forward osmosis     Membrane fouling     Biofouling     Wastewater treatment    

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Preparation and performance of soft actuator based on IPMC with silver electrodes

Qi CHEN, Ke XIONG, Kan BIAN, Ning JIN, Bangfeng WANG,

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 4,   Pages 436-440 doi: 10.1007/s11465-009-0054-5

Abstract: The surface electrodes of traditional ionic polymer-metal composites (IPMC) are made of platinum. To reduce the production cost, nonprecious metals such as silver is proposed. A new approach of electroless silver plating based on chemical deposition method is adopted, getting two types of IPMCs, Pt-Ag IPMC, and Ag-Ag IPMC. The microscopic analysis, driving abilities tests, and their surface-electrode resistance analysis show that Ag and Pt particles penetrate inside Nafion membrane with gradient distribution throughout the membrane. The maximum electro-active bending deformation angles of the specimens, which are obtained under the same specimen dimension and constrains, are about 60° for Pt-Pt IPMC and Pt-Ag IPMC and 90° for the Ag-Ag IPMC, respectively, corresponding to the driving voltage of 3 V, 4 V, and 1.5 V. The surface-electrode resistance of Ag-Ag IPMC is the lowest and the most stable, which shows that the proposed approach is valid. The experiments show that the IPMC technology based on the silver electrode is feasible.

Keywords： ionic polymer-metal composites (IPMC)     Nafion     intelligent material     soft actuators     electroless silver plating    

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: Leptin resistance is a main mechanism of acquired childhood obesity, and the suppression of long form of leptin receptor (OBRb) gene expression in diet-induced obese rats indicates that the down-regulation of OBRb gene expression plays a pivotal role in the mechanism of leptin resistance. The aim of the present study was to construct the lentiviral RNA interference (RNAi) vector of rat OBRb gene and evaluate the effects of siRNA on silencing OBRb gene expression. The target sequence of siRNA-OBRb was designed, and the complementary DNA containing both sense and antisense oligonucleotides was synthesized. After phosphorylation and annealing, these double-stranded DNA was cloned to pRNA-lentivector-VGFP to construct pRNA-Lenti-OBRb-VGFP recombinants with U6-containing promoter, target sequence and Poly III terminator. Then, the products were confirmed by electrophoresis and sequencing analysis, and the effects of RNAi on reducing gene expression were further confirmed by real-time polymerase chain reaction in transfected rat glioma cells expressing OBRb. The target sequence of siRNA-OBRb was successfully cloned to pRNA-lentivector-VGFP, and the RNAi protocol specifically reduced the expression of OBRb mRNA by approximately 80% compared with controls in transfected rat glioma cells. The successful construction of rat lentivirus vectors expressing OBRb-specific shRNA may be useful for further investigation .

Keywords： receptors     leptin     RNA interference     lentivirus vector    

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Characterization of Bacillus amyloliquefacien contaminating 75% alcohol disinfectant

ZHANG Wanming, YUAN Yuesha, BIAN Cangli, TU Xianyu, ZHANG Wen, HUANG Huqiang, WANG Lan

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 113-116 doi: 10.1007/s11684-008-0021-2

Abstract: The clinical characterization of Bacillus amyloliquefacien contaminating 75% alcohol disinfectants were studied. The bacteria were cultured and observed by using bacterial examination under the hospital infection monitor. According to the regulations, the resistance of bacterial to physical and chemical factors was tested. Drug sensitivity tests for 20 commonly used medicines were carried out using a K-B method. The bacterial plasmids were analyzed using the Birnboim method. The bacteria were found after being cultured in the clinically-used 75% alcohol disinfectant fluid. Their total number was more than 800 cfu/mL and they were identified as Bacillus amyloliquefacien. The bacteria were also found to be resistant to boiling for 5 min. It grew well in 95% alcohol disinfectant and was insensitive to 84 disinfectant fluids containing chlorine (1000 mg/L) and such disinfectants as ozone. They were able to be sterilized better through routine ultraviolet exposure for 30 min or gas pressure. The bacteria contained a 2.5 kb plasmid and were sensitive to 13 drugs and insensitive to 7 drugs of the 20 drugs tested. It was suggested that alcohol disinfectant fluid was easily contaminated by Bacillus amyloliquefacien, and the bacteria was resistant to disinfectant fluids such as alcohol and 84 disinfectants
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Modern Marine Ranching: Status and Development Strategy

Que Huayong,Chen Yong,Zhang Xiumei,Zhang Shouyu and Zhang Guofan

Strategic Study of CAE 2016, Volume 18, Issue 3,   Pages 79-84 doi: 10.15302/J-SSCAE-2016.03.013

Abstract:

Modern marine ranching, as a novel fishery production mode, will play an important role in the transformation and up-grade of marine fishery industry in China. This paper presents the status and problems in construction of the modern marine ranching in China through the systematic collation of relevant literature and the combination of the latest research progress, and then puts forward the development strategy from two aspects: the key technology, administration measures.

Keywords： marine ranching     status     development strategy    

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Title Author Date Type Operation

A Dialogue With the Ancient and Reflection on the Interpretation of History of Bian Que and Traditional

Fu Youfeng

Journal Article

Flexible micro flow sensor for micro aerial vehicles

Rong ZHU, Ruiyi QUE, Peng LIU

Journal Article

Five-axis rough machining for impellers

Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI

Journal Article

Retraction Note to: Simulate oil spill weathering with system dynamic model

Aihaiti Kasimu, Junran Dong, Yuan Bian, Desheng WU

Journal Article

Outdoor aging of road asphalt and SBS modified asphalt

Li XIANG, Juan TU, Jian CHENG, Guohe QUE

Journal Article

Current situation and development of prenatal diagnosis in China

Xu-Ming BIAN, Qi GUO, Qing-Wei QI

Journal Article

Adoptive cell transfer therapy for hepatocellular carcinoma

Renyu Zhang, Zhao Zhang, Zekun Liu, Ding Wei, Xiaodong Wu, Huijie Bian, Zhinan Chen

Journal Article

Tests on impact effect of partial fracture at steel frame connections

CHEN Yiyi, BIAN Ruoning

Journal Article

Thermal performance of a single-layer packed metal pebble-bed exposed to high energy fluxes

Shengchun ZHANG, Zhifeng WANG, Hui BIAN, Pingrui HUANG

Journal Article

Simulate oil spill weathering with system dynamic model

Aihaiti KASIMU, Junran DONG, Yuan BIAN, Desheng WU

Journal Article

Simultaneously recovering electricity and water from wastewater by osmotic microbial fuel cells: Performance and membrane fouling

Yuqin Lu, Xiao Bian, Hailong Wang, Xinhua Wang, Yueping Ren, Xiufen Li

Journal Article

Preparation and performance of soft actuator based on IPMC with silver electrodes

Qi CHEN, Ke XIONG, Kan BIAN, Ning JIN, Bangfeng WANG,

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article

Characterization of Bacillus amyloliquefacien contaminating 75% alcohol disinfectant

ZHANG Wanming, YUAN Yuesha, BIAN Cangli, TU Xianyu, ZHANG Wen, HUANG Huqiang, WANG Lan

Journal Article

Modern Marine Ranching: Status and Development Strategy

Que Huayong,Chen Yong,Zhang Xiumei,Zhang Shouyu and Zhang Guofan

Journal Article